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Epinephrine
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| General Principles: | Indications | Precautions | |
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Adrenergic-like drug that can be used as the first catecholamine for persistent or recurrent VF. Also recommended for shock states, in particular for drug-induced (usually in context of an overdose) refractory hypotension and shock. |
Fist line therapy for pulseless rhtythms and asystole. VF, VT, PEA, Asystole | Potent peripheral vasoconstrictor. Increased peripheral vascular resistance may provoke cardiac ischemia and angina. | |
| Note: Available in 1:10000 and 1:1000 concentrations. | Not recommended for responsive patients with coronary artery disease. | ||
| High doses do not improve survival or neurologic outcome and may contribute to postresuscitation myocardial dysfunction. | |||
| Raising blood pressure and increasing heart rate may cause myocardial ischemia, angina, and increased myocardial oxygen demand. | |||
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Cardiac Arrest |
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IV Dose: 1 mg (10 mL of 1:10000 solution) administered every 3 to 5 minutes during resuscitation. | Higher Dose: Higher doses (up to 0.2 mg/kg) may
be used if 1-mg dose fails. Tracheal Route: 2.0 to 2.5 mg diluted in 10 mL normal saline. |
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